(S) -1-Boc-3-hydroxypiperidine
Kufotokozera Kwachidule:
CAS: 143900-44-1
Chithunzi cha C10H19NO3
MW: 201.26
Magulu azinthu
ChiralReagents;Piperidines;Heterocycles;Intermediates & Fine Chemicals;mankhwala; Anticancer
Mawu ofanana ndi mawu
(S) -1-Boc-3-Hydroxypiperidine
(S) -1-N-BOC-3-HYDROXY-PIPERIDINE
(S) -3-HYDROXY-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
(S) -3-HYDROXY-1-(TERT-BUTOXYCARBONYL)PIPERIDINE
(S) -1-BOC-3-PIPERIDINOL
(S)-N-(TERT-BUTOXYCARBONYL)-3-HYDROXYPIPERIDINE HYDROCHLORIDE
(S) -N-BOC-3-HYDROXY PIPERIDINE
(S)-TERT BUTYL-3-HYDROXYPIPERIDINE-1-CARBOXYLATE
(S) -1-(tert-Butoxycarbonyl) -3-hydroxypiperidine
S-1-Boc-3-hydroxypiperidine
(3S) -hydroxy-1-piperidinecarboxylic acid 1,1-dimethylethyl ester
(S) -3,5-DifluoroMandelic asidi
(S) -tert-Butyl 3-hydroxypiperidine-1-carboxylate
(S) -tert-Butyl-3-hydroxypiperidine-1-carboxylate tert-butyl
(3S) -3-hydroxy piperidine-1-carboxylate tert-butyl
(S) -3-hydroxypiperidine-1-carboxylate
(3S) -3-Hydroxypiperidine, N-BOC yotetezedwa
(S) -N-tert-Butoxycarbonyl-3-hydroxypiperidine
Chemical Properties
Malo osungunuka: 34-40 ° C
Malo otentha: 292.3±33.0 °C (Zonenedweratu)
Kachulukidwe: 1.107±0.06 g/cm3(Zonenedweratu)
Fp: 110 °C
Kutentha kosungira: Khalani pamalo amdima, Osindikizidwa owuma, Kutentha kwachipinda
Kusungunuka: Kusungunuka mu methanol.
Pka: 14.74±0.20 (Zonenedweratu)
Fomu: Ufa kapena Crystalline Ufa
Mtundu: Woyera mpaka tani
ntchito ya kuwala: [α]22/D +10.0°, c = 1 mu chloroform
InChIKey: UIJXHKXIOCDSEB-QMMMGPOBSA-N
Chidziwitso changozi
1 Gulu la chinthu kapena kusakaniza
Kukwiya pakhungu, Gawo 2
Kupweteka m'maso, Gawo 2
Chiwopsezo cha chiwalo chandandandandandawu - kuwonekera kamodzi, Gulu 3
2 GHS label zinthu, kuphatikiza mawu osamala
| Zithunzi |  |
| Chizindikiro cha mawu | Chenjezo |
| Ndemanga zangozi | H315 Imayambitsa kuyabwa pakhungu H319 Imayambitsa kuyabwa kwamaso kwambiri H335 ikhoza kuyambitsa kupsa mtima |
| Ndemanga zotetezedwa | |
| Kupewa | P264 Sambani ... bwinobwino mutagwira. P280 Valani magolovesi oteteza / zovala zoteteza / zoteteza maso / zoteteza kumaso / zoteteza kumva / ... P261 Pewani kupuma fumbi/fume/gesi/mist/vapours/spray. P271 Gwiritsirani ntchito panja kapena pamalo olowera mpweya wabwino. |
| Yankho | P302+P352 NGATI PAKHUMBA: Sambani ndi madzi ambiri/... P321 Chithandizo chapadera (onani ... pa chizindikiro ichi). P332+P317 Ngati kuyabwa pakhungu kumachitika: Pezani chithandizo chamankhwala. P362+P364 Chotsani zovala zomwe zili ndi kachilombo ndikuzichapa musanagwiritsenso ntchito. P305+P351+P338 NGATI M'MASO: Sambani mosamala ndi madzi kwa mphindi zingapo.Chotsani magalasi olumikizirana, ngati alipo komanso osavuta kuchita.Pitirizani kutsuka. P304+P340 NGATI WOPHUNZITSIDWA: Chotsani munthu kumpweya watsopano ndikukhala womasuka kupuma. P319 Pezani thandizo lachipatala ngati simukumva bwino. |
| Kusungirako | P403+P233 Sungani pamalo abwino mpweya wabwino.Sungani chidebe chotsekedwa mwamphamvu. P405 Store yatsekedwa. |
| Kutaya | P501 Tayani zamkati/zotengera kumalo oyenera kuchiza ndi kutaya zinthu molingana ndi malamulo ndi malamulo omwe akugwiritsidwa ntchito, komanso mawonekedwe azinthu panthawi yotaya. |
3 Zowopsa zina zomwe sizimayika m'magulu
palibe deta yomwe ilipo
Mafotokozedwe a Zamalonda
| Maonekedwe/mtundu | Yoyera mpaka yoyera yolimba Itha kukhala agglomerate pambuyo posungira nthawi yayitali |
| Identity (IR) | Amafanana |
| Kuyesa (HPLC w/w) | 97.0% -103.0% |
| Chemical purity (GC area) | ﹥﹦ 99.0% |
| Chiyero chonyansa (GC w/w) | 3-Hydroxypiperidine﹤﹦ 0.1% |
| 3-Hydroxypyridine﹤﹦ 0.20% | Sanapezeke |
| 1-Boc-3-piperidone﹤﹦ 0.10% | Sanapezeke |
| 1-Boc-4-hydroxypiperidine﹤﹦ 0.10% | Sanapezeke |
| Mtengo wa 1.96RRT﹤﹦ 0.2% | Sanapezeke |
| Chidetso chilichonse chosadziwika bwino﹤﹦ 0.08% | 0.01% |
| Chiral purity (HPLC area) | ﹥﹦ 99.5% |
| Methanol (GC) | ﹤﹦ 50ppm |
| Ethanol (GC) | ﹤﹦ 50ppm |
| DCM (GC) | ﹤﹦ 500ppm |
| Madzi (KF vol w/w) | ﹤﹦ 0.5% |
Ubwino wathu
1: Fakitale yathu idazindikira kupanga kwakukulu kwamalonda kuyambira chaka cha 2012, kugulitsa kwapachaka kwafika kupitilira 20tons.
2 Wakhala wothandizira woyenerera ku kampani ya mankhwala a patent ya Ibrutinib.
3 Ubwino wazogulitsa ndi wapamwamba: Kuyesa: 97.0% -103.0%
Kuyera kwa Chemical (GC): ﹦ 99.0%
Chidetso chilichonse chosadziwika bwino﹤ ﹦ 0.08%
Chiral purity(HPLC area): ﹥ ﹦ 99.5%
4 Zimapangidwa ndi njira ya Chemical Resolution.
5 Njira zonse zoyesera ndizovomerezeka.
6 Msonkhano umodzi wodzipereka wopangira.
![3-(4-phenoxyphenyl) -1-(3-piperidyl)pyrazolo[3,4-d]pyrimidin-4-amine](http://cdn.globalso.com/hengkangpharma/1657269157159-300x300.png)
![5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyriMidin-4-ylaMine](http://cdn.globalso.com/hengkangpharma/1657269546537-300x300.png)
